Background: In the past decade there has been a rapid increase in the use of mobile devices, particularly smartphones, for communication and internet browsing. Extensive use of smartphones can be linked with physical health-related problems such as pain in the wrist and neck, and can lead to musculoskeletal disorders of the hand and thumb. A repetitive stress injury, also known as overuse syndrome is where a person has his/her hand positioned in the same fashion and posture for sustained periods of time. The incidence of musculoskeletal disorders (MSD) of hand, wrist, forearm, arm and neck has been increasing all over the world due to prolonged, forceful, low amplitude, repetitive use of hand-held devices (HHDs). Therefore, in this study, with the help of Hand and Pinch strengthening exercises we are trying to improve the respective grips of the affected population. Purpose of Study: To study the effect of Hand grip exercises over Pain, Handgrip and Pinch grip in smartphone addicted population. Materials and Methodology: 63 participants were recruited and screened from College of Physiotherapy, Wanless Hospital, Miraj aged between 18-25 years, classified as ‘addicted’ according to SAS-SV and self-reported Pain (NPRS) after Smartphone use. Study design was randomized clinical trial with purposive sampling method. After taking written consent from them, their Handgrip as well as pinch grip were measured by Hand-held dynamometer and Pinch meter respectively. A 4-week Grip strengthening protocol was followed and post intervention Pain and Grip was assessed. Results: There is a significant statistical reliable difference between the pre & post treatment values in NPRS, Hand Grip strength (HGS), Pinch strength (PS) with p-value is less than the 5% significance level (i.e., 0.001 < 0.05) in the study. Conclusion: There is significant decrease in the NPRS values and a significant increase Hand grip and Pinch grip on dominant hand who underwent hand muscle strengthening exercises. So, the strengthening exercises are beneficial to improve HS, GS and Pain.