Chondromalacia patellae (CMP) is usually described as an overload injury, caused by malalignment of the femur to the patella and the tibia. Chondromalacia patellae also occur as a result of trauma to the chondrocytes in the articular cartilage (leading to proteolytic enzymatic digestion of the superficial matrix). Adolescents and young adults (age group 17–35 years) are commonly affected. Active young adults who participate in running sports or workers who increase stress in their patellofemoral joint by repeated stair climbing and/or kneeling have a higher incidence of chondromalacia. Exercises and activities that require deep knee bending, jumping and landing, pushing or pulling heavy loads and stopping and starting will place very high stresses on the patellofemoral joint and the patellar tendon. So, those activities should be avoided. Initial treatment for chondromalacia patellae includes rest and vitamin D, but these therapies do not regenerate cartilage. The primary goal for treatment and rehabilitation of chondromalacia patellae is to relieving the pain. Initial pain management involves avoiding motions which irritate the kneecap.