The purpose of this study was to compare the effect of positional release technique and deep transverse friction massage on pain and disability along with therapeutic exercises in patients with mechanical neck pain. 30 subjects, including both males and females, aged from 18 to 45 years. Patients were allocated randomly into 2 groups. Group a patients received positional release technique and Group B deep transverse friction massage. Pain intensity level and disability was measured using numeric pain rating scale (NPRS), neck disability index (NDI) and respectively pre and post intervention i.e. after 4 weeks intervention. There was significant improvement in both PRT and DTFM groups. Statistical comparison of the result showed that Group A had greater improvement in pain and disability as compared to Group B. PRT along with therapeutic exercises appeared to be more effective than DTFM to reduce pain and disability in patients with mechanical neck pain.