The endeavour of the present study was to see the impact of lower limb biomechanical alignments on the magnitude of Quadriceps angle between university level male sprinters and sedentary young males. 50 male university level sprinters and 50 sedentary young males of age group 18-28 years were included purposively from Odisha for the study. All the selected lower limb biomechanical alignment variables were recorded thrice and median value considered as criterion to eradicate error. Selected variables such as height, weight, Body Mass Index, total leg length, lower leg length, tibiofemoral angle, femoral anteversion, Quadriceps angle, genu recurvatum, tibial torsion, and navicular drop were measured on each subject following standard techniques. The Results showed right and left Quadriceps angles have highly significant positive correlation (p≤0.001) with right and left femoral anteversion, tibial torsion and navicular drop. On the basis of results of the study, it may be concluded that femoral anteversion, tibial torsion and navicular drop have significant impact on the magnitude of the Quadriceps angle.