Objective: Objective of the study was to check the effectiveness of power yoga on body mass index, mental health and Quality of life in overweight and grade 1 obese postmenopausal females by the end of 6 weeks. Subjects and methods: In this study total 40 females were included within age group 45-55 years having BMI between 25kg/m²-34.9kg/m², females having mild to moderated symptoms on beck depression scale i.e score 11 and more, females who at least have mild menopausal symptoms i.e 5 points on MRS. we included 10 minutes of warm up which includes 5 rounds of sun salutations followed by various yoga postures in standing and sitting with choreographed sequence which flows from one posture to other and is co-ordinated with breathing. In the end 10 minutes of cool down exercise including Jacobson’s relaxation was performed for 6 weeks duration (5 days per week). Results: Mean score of BMI improved from 29.43 to 28.64, mean score of BDS was improved from 19.52 to 15.95 and mean score of MENQOL was improved from 164.4 to 152.42. Conclusion: Power Yoga showed significant effect on weight, mental health and quality of life in postmenopausal overweight and grade 1 obese females by the end of 6 weeks.