An unusual case of cardiomyopathy, cerebral and cerebellar atrophy with depression was presented in a 29 years male patient. The patient came to physiotherapy department with complaints of imbalance, in coordination, slurred speech and difficulty in walking. His last echocardiogram suggested left ventricular ejection fraction of 40% with moderate left ventricular systolic dysfunction, mild aortic regurgitation and dilated cardiomyopathy. MRI findings suggested diffuse cerebral and cerebellar atrophy with gliotic areas in bilateral frontal, parietal and right posterior medial temporal cortex. Patient scored low in six minute walk test and short term memory deficit was apparent on examination.