This study was undertaken with the objective to evaluate the efficacy of Yoga in management of pain, in patients suffering from Primary Osteoarthritis of the knee. An intervention program was developed for the planned study incorporating Yoga components such as relaxation posture (Shavasana) and breathing exercise (Pranayama). A sample of 50 patients was selected and a single within group design with pre, post and follow up assessment was adopted for the purpose. Assessment was done using Western Ontario Macmaster Osteoarthritis Index modified at Centre for Rheumatic Diseases, Pune. Following intervention, the sample showed a significant difference and decline in pain thus demonstrating the effectiveness of yoga practices in the management of Osteoarthritis of the knee.