Sinusitis headache is an inflammatory disorder. Yogic techniques have the potentiality to prevent and cure such conditions by relieving the inflammation and by increasing the resistance against the infection. The efficacy of the yoga therapy on Sinusitis headache was studied with 20 sinusitis patients of age group 19-53 years along with a control group during the present study. Yoga therapy was given for a period of 6 months including follow-up. The temperature variation recorded by Infra-Red Thermal Imaging System (IRTIS) was selected as the main parameter for the present study. Similarly the blood tests for ESR, Total W.B.C. count and Differential count were also considered as other parameters. The experimental group has shown a highly significant change in the IRTIS reading in both right and left frontal sinus areas with p <0.001. This is also correlated by the significant improvement in the blood test readings. These statistical significant changes were not seen in control group. This shows that yoga therapy helped to relieve the inflammation in Frontal Sinusitis headache and improved the resistance of the body against the infection.