There is growing literature on effects of physical activity on motor deficiency and sedentary life style in autism spectrum disorder (ASD). It appears there is however, little information on the positive effects of exergames on ASD. This study is aimed at reviewing the current studies on the role of exergames on improving sedentary lifestyle and motor skill in ASD. Scientific journals were searched for studies on ASD and benefits of exergames on motor skill and physical inactivity. These journals include pubmed, medline and google scholar. The results of this study confirm that Exergames are very effective interventions for improving motor skill and physical activity in ASD. In addition, exergames elicit maximum form of entertainment which could encourage active participation and consequently improve the conditions of the participants. Thus, exergames may provide alternative intervention to traditional exercise.