Background: With the increasing dependence on visual display terminals (VDTs), prolonged computer usage has become a routine occupational demand, particularly in sectors such as administration, finance, education, and healthcare. Over the past two decades, research has consistently reported that VDT workers are at increased risk of musculoskeletal disorders (MSDs), particularly in the spine and upper limbs.

Aim: To determine the prevalence of musculoskeletal disorders among desktop users in corporate office settings.

Methodology: A cross-sectional survey was conducted among 253 corporate employees, selected through simple random sampling from an initial pool of 264 eligible participants. Inclusion criteria were individuals aged 25–50 years, engaged in desktop work for a minimum of 15 hours per week, and with at least one year of work experience. Exclusion criteria included history of recent trauma, orthopedic conditions unrelated to occupational exposure (e.g., road traffic accidents, fractures), and individuals above 50 years of age. Data on musculoskeletal complaints were collected using the Standardized Nordic Musculoskeletal Questionnaire after informed consent.

Results: MSD prevalence over the past 12 months was reported at 82.21%. The lower back was the most frequently affected region (58.65%), followed by the upper back, neck, and shoulders. A higher prevalence of MSDs was observed in individuals with elevated BMI and in those with less than 10 years of work experience. Younger participants also showed a higher rate of complaints compared to older counterparts within the study range.