Background: Carpal tunnel syndrome (CTS) is a common medical condition and one of the most frequently reported forms of median nerve compression. CTS occurs when the median nerve is squeezed or compressed as it travels through the wrist. The syndrome is characterized by hand pain, numbness, and tingling in the distribution of the median nerve. Risk factors for CTS include obesity, repetitive wrist activity, pregnancy, genetic predisposition, and rheumatoid inflammation.

Aim: This study aims to review relevant literature and synthesize knowledge regarding the effectiveness of manual therapy in treating carpal tunnel syndrome among computer professionals.

Search Method: The databases used for searching articles included Pub Med, Research Gate, Google Scholar, Science Direct, and Cochrane. A total of 80 articles from the past 10 years were collected.

Selection Criteria: Selection criteria included studies on patients with carpal tunnel syndrome, focusing on the effectiveness of manual therapy in terms of pain relief, improvement in range of motion, and visual analog scale measurements.

Results: Four studies met the inclusion criteria and were included in the review. The methods used in these studies primarily involved neurodynamics.